CDKN2A monoclonal antibody, clone DCS-50
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Specifications
Product Description
Mouse monoclonal antibody raised against recombinant CDKN2A.
Immunogen
Recombinant protein corresponding to human CDKN2A.
Host
Mouse
Theoretical MW (kDa)
16
Reactivity
Human
Form
Lyophilized
Isotype
IgG1
Recommend Usage
Immunocytochemistry (1 ug/mL)
Immunohistochemistry (Frozen sections) (1-2 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from mouse ascites fluid, 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide).
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of PBS buffer will yield a concentration of 100 ug/mL, store at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunocytochemistry
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Gene Info — CDKN2A
Entrez GeneID
1029Gene Name
CDKN2A
Gene Alias
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19
Gene Description
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Gene Ontology
HyperlinkGene Summary
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq
Other Designations
CDK4 inhibitor p16-INK4|OTTHUMP00000021147|OTTHUMP00000021148|cell cycle negative regulator beta|cyclin-dependent kinase inhibitor 2A|cyclin-dependent kinase inhibitor p16|multiple tumor suppressor 1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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CDKN2A mutations in multiple primary melanomas.
Monzon J, Liu L, Brill H, Goldstein AM, Tucker MA, From L, McLaughlin J, Hogg D, Lassam NJ.
The New England Journal of Medicine 1998 Mar; 338(13):879.
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Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas.
Bartsch D, Shevlin DW, Tung WS, Kisker O, Wells SA Jr, Goodfellow PJ.
Genes, Chromosomes & Cancer 1995 Nov; 14(3):189.
Application:WB-Ti, Human, Human pancreatic Adenocarcinomas.
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Complex structure and regulation of the P16 (MTS1) locus.
Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A.
Cancer Research 1995 Jul; 55(14):2988.
Application:WB-Ce, Human, Mouse, T cells.
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CDKN2A mutations in multiple primary melanomas.
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