HCG Holo monoclonal antibody, clone HCGab/52
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Specification
Product Description
Mouse monoclonal antibody raised against intact-HCG.
Immunogen
Native purified hCG protein.
Host
Mouse
Reactivity
Human
Specificity
Reacts only with the intact-HCG and not with either free alpha- or free beta-chain of HCG.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with HCG Holo monoclonal antibody, clone HCGab/52 (Cat # MAB14713). -
Gene Info — CGA
Entrez GeneID
1081Gene Name
CGA
Gene Alias
CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA
Gene Description
glycoprotein hormones, alpha polypeptide
Omim ID
118850Gene Ontology
HyperlinkGene Summary
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. [provided by RefSeq
Other Designations
OTTHUMP00000016825|chorionic gonadotropin, alpha polypeptide|follicle-stimulating hormone alpha subunit
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Gene Info — CGB
Entrez GeneID
1082Gene Name
CGB
Gene Alias
CGB3, hCGB
Gene Description
chorionic gonadotropin, beta polypeptide
Omim ID
118860Gene Ontology
HyperlinkGene Summary
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq
Other Designations
chorionic gonadotropin beta 3 subunit|chorionic gonadotropin beta chain|chorionic gonadotropin beta subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Adiponectin attenuation of endocrine function within human term trophoblast cells.
McDonald EA, Wolfe MW.
Endocrinology 2009 Sep; 150(9):4358.
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Adiponectin attenuation of endocrine function within human term trophoblast cells.
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