MYADM monoclonal antibody, clone MYADM/972
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Specification
Product Description
Mouse monoclonal antibody raised against human MYADM.
Immunogen
Recombinant protein corresponding to human MYADM.
Host
Mouse
Reactivity
Human
Specificity
Recognizes a myeloid associated differentiation antigen in the cytoplasm of mature granulocytes. It shows no reactivity with any other cell type in human tissues.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (1-2 ug/million cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with MYADM monoclonal antibody, clone MYADM/972 (Cat # MAB14707).Immunofluorescence
Flow Cytometry
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Gene Info — MYADM
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Interactome
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Publication Reference
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MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
Aranda JF, Reglero-Real N, Marcos-Ramiro B, Ruiz-Sáenz A, Fernández-Martín L, Bernabé-Rubio M, Kremer L, Ridley AJ, Correas I, Alonso MA, Millán J.
Molecular Biology of the Cell 2013 Feb; 24(4):483.
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MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.
Aranda JF, Reglero-Real N, Kremer L, Marcos-Ramiro B, Ruiz-Sáenz A, Calvo M, Enrich C, Correas I, Millán J, Alonso MA.
Molecular Biology of the Cell 2011 Apr; 22(8):1252.
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Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells.
Wang Q, Li N, Wang X, Shen J, Hong X, Yu H, Zhang Y, Wan T, Zhang L, Wang J, Cao X.
Life Sciences 2007 Jan; 80(5):420.
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Cloning of human myeloid-associated differentiation marker (MYADM) gene whose expression was up-regulated in NB4 cells induced by all-trans retinoic acid.
Cui W, Yu L, He H, Chu Y, Gao J, Wan B, Tang L, Zhao S.
Molecular Biology Reports 2001 Sep; 28(3):123.
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Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation.
Pettersson M, Dannaeus K, Nilsson K, Jönsson JI.
Journal of Leukocyte Biology 2002 May; 67(5):425.
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MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.
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