ITGAM monoclonal antibody, clone ITGAM/271
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human ITGAM.
Immunogen
Recombinant protein corresponding to human ITGAM.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Flow Cytometry
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Gene Info — ITGAM
Entrez GeneID
3684Gene Name
ITGAM
Gene Alias
CD11B, CR3A, MAC-1, MAC1A, MGC117044, MO1A, SLEB6
Gene Description
integrin, alpha M (complement component 3 receptor 3 subunit)
Omim ID
120980Gene Ontology
HyperlinkGene Summary
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
antigen CD11b (p170)|complement component receptor 3, alpha|integrin alpha M|macrophage antigen alpha polypeptide|neutrophil adherence receptor alpha-M subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets.
Flotte TJ, Springer TA, Thorbecke GJ.
The American Journal of Pathology 1983 Apr; 111(1):112.
Application:IHC-Fr, Mouse, Epidermal sheets, Small intestine, Thymus.
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Biosynthesis and assembly of the alpha and beta subunits of Mac-1, a macrophage glycoprotein associated with complement receptor function.
Ho MK, Springer TA.
The Journal of Biological Chemistry 1983 Mar; 258(5):2766.
Application:IP, Mouse, Mouse macrophages, P388D1 cells.
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LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.
Springer TA, Davignon D, Ho MK, Kürzinger K, Martz E, Sanchez-Madrid F.
Immunological Reviews 1982 Dec; 68:171.
Application:Func, IP, Flow Cyt, Human, Sheep, Erythrocytes, Granulocytes, Mcrophages, Natural killer, Spleen cells.
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Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells.
Ault KA, Springer TA.
Journal of Immunology 1981 Jan; 126(1):359.
Application:Flow Cyt, Func, Human, Monocytes, Natural killer cells.
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Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens.
Springer T, Galfrè G, Secher DS, Milstein C.
European Journal of Immunology 1978 Aug; 8(8):539.
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Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets.
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