Mouse monoclonal antibody raised against partial recombinant human RB1.
Recombinant protein corresponding to a 283 amino acid fragment of human RB1.
Theoretical MW (kDa):
Protein G purification
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 - 2 ug/mL) Immunoprecipitation (0.5 - 1 ug/500 ug protein lysate) Western Blot (0.5 - 1 ug/mL) The optimal working dilution should be determined by the end user.
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
OTTHUMP00000018397,retinoblastoma suspectibility protein,retinoblastoma-associated protein