RB1 monoclonal antibody, clone 1F8
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human RB1.
Immunogen
Recombinant protein corresponding to a 283 amino acid fragment of human RB1.
Host
Mouse
Theoretical MW (kDa)
105
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 - 2 ug/mL)
Immunoprecipitation (0.5 - 1 ug/500 ug protein lysate)
Western Blot (0.5 - 1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon with RB1 monoclonal antibody, clone 1F8 (Cat # MAB14671).Immunoprecipitation
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Gene Info — RB1
Entrez GeneID
5925Protein Accession#
P06400Gene Name
RB1
Gene Alias
OSRC, RB, p105-Rb, pRb, pp110
Gene Description
retinoblastoma 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018397|retinoblastoma suspectibility protein|retinoblastoma-associated protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Cellular localization and T antigen binding of the retinoblastoma protein.
Bártek J, Vojtĕsek B, Grand RJ, Gallimore PH, Lane DP.
Oncogene 1992 Jan; 7(1):101.
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The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.
Grand RJ, Byrd PJ, Grabham PW, Gregory CD, Huen DS, Merrick RM, Young LS, Gallimore PH.
Oncogene 1989 Nov; 4(11):1291.
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Cellular localization and T antigen binding of the retinoblastoma protein.
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