VEGFA monoclonal antibody, clone VEGF/1063
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human VEGFA.
Immunogen
Recombinant protein corresponding to full length human VEGFA isoform VEGFA189.
Host
Mouse
Theoretical MW (kDa)
19-22, 38-44
Reactivity
Human
Specificity
This antibody is highly specific to VEGFA and recognizes the 19-22kDa (reducing) and 38-44kDa (non-reducing) form of VEGFA.
Form
Liquid
Purification
Protein G purification
Isotype
IgG1, kappa
Recommend Usage
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS.
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with VEGFA monoclonal antibody, clone VEGF/1063 (Cat # MAB14647).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ovarian carcinoma with VEGFA monoclonal antibody, clone VEGF/1063 (Cat # MAB14647).Immunofluorescence
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Gene Info — VEGFA
Entrez GeneID
7422Protein Accession#
P15692-2Gene Name
VEGFA
Gene Alias
MGC70609, VEGF, VEGF-A, VPF
Gene Description
vascular endothelial growth factor A
Gene Ontology
HyperlinkGene Summary
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq
Other Designations
vascular endothelial growth factor isoform VEGF165|vascular permeability factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.
Berse B, Brown LF, Van de Water L, Dvorak HF, Senger DR.
Molecular Biology of the Cell 1992 Feb; 3(2):211.
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The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.
Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA.
The Journal of Biological Chemistry 1991 Jun; 266(18):11947.
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Induction of angiogenesis during the transition from hyperplasia to neoplasia.
Folkman J, Watson K, Ingber D, Hanahan D.
Nature 1989 May; 339(6219):58.
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Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.
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