TGM2 monoclonal antibody, clone SPM358
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of (A) human tonsil (B) human placenta (C) human uterus and (D) human leiomyosarcoma with TGM2 monoclonal antibody, clone SPM358 (Cat # MAB14616).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human TGFA.
Immunogen
Recombinant protein corresponding to full length human TGM2.
Host
Mouse
Theoretical MW (kDa)
77-85
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of (A) human tonsil (B) human placenta (C) human uterus and (D) human leiomyosarcoma with TGM2 monoclonal antibody, clone SPM358 (Cat # MAB14616).Immunofluorescence
Flow Cytometry
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Gene Info — TGM2
Entrez GeneID
7052Protein Accession#
P21980Gene Name
TGM2
Gene Alias
G-ALPHA-h, GNAH, TG2, TGC
Gene Description
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Omim ID
190196Gene Ontology
HyperlinkGene Summary
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
C polypeptide|OTTHUMP00000030960|TGase C|TGase-H|protein-glutamine-gamma-glutamyltransferase|tissue transglutaminase|transglutaminase 2|transglutaminase C
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Interactome
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Disease
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Publication Reference
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Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.
Yamanishi K, Liew FM, Konishi K, Yasuno H, Doi H, Hirano J, Fukushima S.
Biochemical and Biophysical Research Communications 1991 Mar; 175(3):906.
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Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.
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