SOX10 monoclonal antibody, clone SOX10/991
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human SOX10.
Immunogen
Recombinant protein corresponding to amino acids 115-269 of human SOX10.
Host
Mouse
Theoretical MW (kDa)
49-58
Reactivity
Human, Mouse
Specificity
Recognizes a protein of ~55 kDa, identified as SOX10. This antibody is highly specific and does not cross-react with other members of the SOX-family.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of (A) human melanoma and (B) mouse brain with SOX10 monoclonal antibody, clone SOX10/991 (Cat # MAB14608).Immunofluorescence
Flow Cytometry
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Gene Info — SOX10
Entrez GeneID
6663Protein Accession#
P56693Gene Name
SOX10
Gene Alias
DOM, MGC15649, WS2E, WS4
Gene Description
SRY (sex determining region Y)-box 10
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq
Other Designations
OTTHUMP00000028515|OTTHUMP00000195094|SRY-related HMG-box gene 10|dominant megacolon, mouse, human homolog of
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Interactome
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Disease
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Publication Reference
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SOX10 Expression in malignant melanoma, carcinoma, and normal tissues.
Mohamed A, Gonzalez RS, Lawson D, Wang J, Cohen C.
Applied Immunohistochemistry & Molecular Morphology 2013 Dec; 21(6):506.
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SOX10 Expression in malignant melanoma, carcinoma, and normal tissues.
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