ACTA2 monoclonal antibody, clone ACTA2/791
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human ACTA2.
Immunogen
Recombinant protein corresponding to full length human ACTA2.
Host
Mouse
Theoretical MW (kDa)
42
Reactivity
Human, Rat
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of (A) human angiosarcoma (B) human leiomyosarcoma (C) rat lung with ACTA2 monoclonal antibody, clone ACTA2/791 (Cat # MAB14599).Immunofluorescence
Flow Cytometry
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Gene Info — ACTA2
Entrez GeneID
59Protein Accession#
P62736Gene Name
ACTA2
Gene Alias
AAT6, ACTSA
Gene Description
actin, alpha 2, smooth muscle, aorta
Omim ID
102620Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000020042|alpha 2 actin|alpha-cardiac actin|growth-inhibiting gene 46
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Interactome
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Pathway
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Disease
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Publication Reference
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A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes.
Gown AM, Vogel AM, Gordon D, Lu PL.
The Journal of Cell Biology 1985 Mar; 100(3):807.
Application:IF, IHC-P, WB-Ce, WB-Ti, Human, Rat, Human Leiomyosarcoma, Rat aortic smooth muscle cells.
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A smooth muscle-specific monoclonal antibody recognizes smooth muscle actin isozymes.
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