JUP monoclonal antibody, clone 11 E4
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human JUP.
Immunogen
Recombinant MBP fusion protein corresponding to full length human JUP.
Host
Mouse
Theoretical MW (kDa)
80-87
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Flow Cytometry
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Gene Info — JUP
Entrez GeneID
3728Protein Accession#
P14923Gene Name
JUP
Gene Alias
ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB
Gene Description
junction plakoglobin
Gene Ontology
HyperlinkGene Summary
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq
Other Designations
OTTHUMP00000164735|catenin (cadherin-associated protein), gamma (80kD)|catenin (cadherin-associated protein), gamma 80kDa|gamma-catenin
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.
Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR.
The Journal of Biological Chemistry 1995 Aug; 270(34):20201.
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P- and E-cadherin are in separate complexes in cells expressing both cadherins.
Johnson KR, Lewis JE, Li D, Wahl J, Soler AP, Knudsen KA, Wheelock MJ.
Experimental Cell Research 1993 Aug; 207(2):252.
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Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.
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