IFNG monoclonal antibody, clone IFNG/466
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human IFNG.
Immunogen
Recombinant protein corresponding to full length human IFNG.
Host
Mouse
Theoretical MW (kDa)
20-25
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human renal cell carcinoma (A, C) and human testicular carcinoma (B) with IFNG monoclonal antibody, clone IFNG/466 (Cat # MAB14562).Immunofluorescence
Flow Cytometry
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Gene Info — IFNG
Entrez GeneID
3458Protein Accession#
P01579Gene Name
IFNG
Gene Alias
IFG, IFI
Gene Description
interferon, gamma
Gene Ontology
HyperlinkGene Summary
Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNG in the immune system stems in part from its ability to inhibit viral replication directly, but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, 2007 [PubMed 17981204]).[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Forty years of interferon, forty years of cytokines.
Vilcek J.
Cytokine & Growth Factor Reviews 1997 Dec; 8(4):239.
Application:ELISA, Human, Immune cells.
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The molecular cell biology of interferon-gamma and its receptor.
Farrar MA, Schreiber RD.
Annual Review of Immunology. 1993 Apr; 11:571.
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Induction of human interferon gamma with phorbol esters and phytohemagglutinin.
J Vilcek, J M Le, Y K Yip.
Methods in Enzymology 1986 Jan; 119:48.
Application:ELISA, Neutralization, Human, Human T cell lymphoma lines, Hut 102-B2 cells.
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Forty years of interferon, forty years of cytokines.
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