KDR monoclonal antibody, clone KDR-1
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant KDR.
Immunogen
Recombinant protein corresponding to full length human KDR.
Host
Mouse
Theoretical MW (kDa)
151.5
Reactivity
Human
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western Blot (0.5-1 ug/mL)
Immunohistochemistry (Frozen sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
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Gene Info — KDR
Entrez GeneID
3791Gene Name
KDR
Gene Alias
CD309, FLK1, VEGFR, VEGFR2
Gene Description
kinase insert domain receptor (a type III receptor tyrosine kinase)
Gene Ontology
HyperlinkGene Summary
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq
Other Designations
soluble VEGFR2|vascular endothelial growth factor receptor 2
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Interactome
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Pathway
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Disease
- Adenocarcinoma
- Alzheimer disease
- Angina Pectoris
- Anoxia
- Asthma
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
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Publication Reference
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Angiogenesis in cancer, vascular, rheumatoid and other disease.
Folkman J.
Nature Medicine 1995 Jan; 1(1):27.
Application:ELISA, Human, Blood, Tumors.
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Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant.
Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A.
Nature 1994 Feb; 367(6463):576.
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Angiogenesis in cancer, vascular, rheumatoid and other disease.
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