ELA3B monoclonal antibody, clone CELA3B/1811
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: recombinant protein and Lane 2: human pancreas tissue lysate with ELA3B monoclonal antibody, clone CELA3B/1811 (Cat # MAB14531).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ELA3B.
Immunogen
Recombinant protein corresponding to amino acids 82-238 of human ELA3B.
Host
Mouse
Theoretical MW (kDa)
~17
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: recombinant protein and Lane 2: human pancreas tissue lysate with ELA3B monoclonal antibody, clone CELA3B/1811 (Cat # MAB14531).Immunofluorescence
Flow Cytometry
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Gene Info — ELA3B
Entrez GeneID
23436Protein Accession#
P08861Gene Name
ELA3B
Gene Alias
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Gene Description
elastase 3B, pancreatic
Gene Ontology
HyperlinkGene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq
Other Designations
OTTHUMP00000002837|elastase 1|elastase 3B|protease E
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Interactome
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Publication Reference
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Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.
Shimada S, Yamaguchi K, Takahashi M, Ogawa M.
International Journal of Molecular Medicine 2002 Nov; 10(5):599.
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Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.
Tani T, Ohsumi J, Mita K, Takiguchi Y.
The Journal of Biological Chemistry 1998 Jan; 263(3):1231.
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Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.
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