DSG3 monoclonal antibody, clone DSG3/1535
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human DSG3.
Immunogen
Recombinant protein corresponding to extracellular domain of human DSG3.
Host
Mouse
Theoretical MW (kDa)
130
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung squamous cell carcinoma (A) and human skin (B) with DSG3 monoclonal antibody, clone DSG3/1535 (Cat # MAB14506).Immunofluorescence
Flow Cytometry
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Gene Info — DSG3
Entrez GeneID
1830Protein Accession#
P32926Gene Name
DSG3
Gene Alias
CDHF6, DKFZp686P23184, PVA
Gene Description
desmoglein 3 (pemphigus vulgaris antigen)
Omim ID
169615Gene Ontology
HyperlinkGene Summary
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq
Other Designations
130-kD pemphigus vulgaris antigen|desmoglein 3|pemphigus vulgaris antigen
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Interactome
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Disease
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Publication Reference
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The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung.
Savci-Heijink CD, Kosari F, Aubry MC, Caron BL, Sun Z, Yang P, Vasmatzis G.
The American Journal of Pathology 2009 May; 174(5):1629.
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The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung.
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