DSG3 monoclonal antibody, clone 5G11
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with DSG3 monoclonal antibody, clone 5G11 (Cat # MAB14504).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human DSG3.
Immunogen
Recombinant protein corresponding to extracellular domain of human DSG3.
Host
Mouse
Theoretical MW (kDa)
130
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with DSG3 monoclonal antibody, clone 5G11 (Cat # MAB14504).Immunofluorescence
Flow Cytometry
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Gene Info — DSG3
Entrez GeneID
1830Protein Accession#
P32926Gene Name
DSG3
Gene Alias
CDHF6, DKFZp686P23184, PVA
Gene Description
desmoglein 3 (pemphigus vulgaris antigen)
Omim ID
169615Gene Ontology
HyperlinkGene Summary
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [provided by RefSeq
Other Designations
130-kD pemphigus vulgaris antigen|desmoglein 3|pemphigus vulgaris antigen
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Interactome
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Disease
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Publication Reference
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Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK 3rd.
Experimental Dermatology 2006 Feb; 15(2):101.
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Generation of monoclonal antibodies specific for desmoglein family members.
Wahl JK 3rd.
Hybridoma and Hybridomics 2002 Feb; 21(1):37.
Application：IF, IP, WB-Tr, Human, A-431D cells.
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Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
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