DSC2/DSC3 monoclonal antibody, clone 7G6
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with DSC2/DSC3 monoclonal antibody, clone 7G6 (Cat # MAB14498).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human DSC2/DSC3.
Immunogen
Recombinant protein corresponding to extracellular domain of human DSC2.
Host
Mouse
Theoretical MW (kDa)
110, 100
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human skin with DSC2/DSC3 monoclonal antibody, clone 7G6 (Cat # MAB14498).Immunofluorescence
Flow Cytometry
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Gene Info — DSC2
Entrez GeneID
1824Protein Accession#
Q02487;Q14574Gene Name
DSC2
Gene Alias
ARVD11, CDHF2, DG2, DGII/III, DKFZp686I11137, DSC3
Gene Description
desmocollin 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
desmosomal glycoprotein II/III
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Gene Info — DSC3
Entrez GeneID
1825Protein Accession#
Q02487;Q14574Gene Name
DSC3
Gene Alias
CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP
Gene Description
desmocollin 3
Omim ID
600271Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
desmocollin 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Nomenclature of the desmosomal cadherins.
Buxton RS, Cowin P, Franke WW, Garrod DR, Green KJ, King IA, Koch PJ, Magee AI, Rees DA, Stanley JR, et al.
The Journal of Cell Biology 1993 May; 121(3):481.
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Nomenclature of the desmosomal cadherins.
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