Mouse monoclonal antibody raised against full length recombinant CCND1.
Recombinant protein corresponding to full length human CCND1.
Theoretical MW (kDa):
Human, Mouse, Rat
Western Blot (4 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (8 ug/mL) Immunohistochemistry (Frozen sections) (8 ug/mL) The optimal working dilution should be determined by the end user.
Store at -20°C on dry atmosphere. After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq