CDH3 monoclonal antibody, clone 12H6
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human CDH3.
Immunogen
Recombinant protein corresponding to full length human CDH3.
Host
Mouse
Theoretical MW (kDa)
116
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Flow Cytometry
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Gene Info — CDH3
Entrez GeneID
1001Protein Accession#
P22223Gene Name
CDH3
Gene Alias
CDHP, HJMD, PCAD
Gene Description
cadherin 3, type 1, P-cadherin (placental)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq
Other Designations
cadherin 3, type 1|calcium-dependent adhesion protein, placental
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Interactome
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Pathway
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Disease
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Publication Reference
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Aberrant P-cadherin expression is a feature of clonal expansion in the gastrointestinal tract associated with repair and neoplasia.
Sanders DS, Perry I, Hardy R, Jankowski J.
The Journal of Pathology 2000 Apr; 190(5):526.
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Aberrant P-cadherin expression is a feature of clonal expansion in the gastrointestinal tract associated with repair and neoplasia.
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