TYR monoclonal antibody, clone OCA1/812
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human TYR.
Immunogen
Recombinant protein corresponding to full length human TYR.
Host
Mouse
Theoretical MW (kDa)
70-80
Reactivity
Human
Specificity
Recognizes a cluster of proteins between 70-80kDa, identified as TYR. Occasionally a minor band at 55kDa is also detected. This antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells in 0.1 mL)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human melanoma with TYR monoclonal antibody, clone OCA1/812 (Cat # MAB14457).Immunofluorescence
Flow Cytometry
-
Gene Info — TYR
Entrez GeneID
7299Protein Accession#
P14679Gene Name
TYR
Gene Alias
OCA1A, OCAIA, SHEP3
Gene Description
tyrosinase (oculocutaneous albinism IA)
Gene Ontology
HyperlinkGene Summary
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq
Other Designations
tyrosinase
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Mammalian tyrosinase--the critical regulatory control point in melanocyte pigmentation.
Hearing VJ, Jiménez M.
The International Journal of Biochemistry 1987 Jan; 19(12):1141.
Application:IHC, WB-Ce, WB-Tr, Human, Eyes, Hair bulbs, Mammalian cells, Melanocytes, Skin.
-
Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin.
Körner A, Pawelek J.
Science 1982 Sep; 217(4565):1163.
Application:WB-Ce, WB-Tr, Human, Mammalian cells.
-
Mammalian tyrosinase--the critical regulatory control point in melanocyte pigmentation.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com