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TYR monoclonal antibody, clone OCA1/812

  • Catalog # : MAB14457
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant human TYR.
  • Immunogen:
  • Recombinant protein corresponding to full length human TYR.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 70-80
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes a cluster of proteins between 70-80kDa, identified as TYR. Occasionally a minor band at 55kDa is also detected. This antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75.
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/million cells in 0.1 mL)
    Immunofluorescence (1-2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS (0.05% BSA and 0.05% azide).
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human melanoma with TYR monoclonal antibody, clone OCA1/812 (Cat # MAB14457).
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 7299
  • Gene Name:
  • TYR
  • Gene Alias:
  • OCA1A,OCAIA,SHEP3
  • Gene Description:
  • tyrosinase (oculocutaneous albinism IA)
  • Gene Summary:
  • The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq
  • Other Designations:
  • tyrosinase
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