Macrophage monoclonal antibody, clone MAC387
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with Macrophage monoclonal antibody, clone MAC387 (Cat # MAB14434).
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Specification
Product Description
Mouse monoclonal antibody raised against macrophage L1 protein.
Immunogen
Affinity purified monocyte membrane preparation.
Host
Mouse
Theoretical MW (kDa)
12-14
Reactivity
Human
Specificity
Recognizes the L1 or calprotectin molecule, an intra-cytoplasmic antigen comprising of a 12kDa alpha chain and a 14kDa beta chain expressed by granulocytes, monocytes and by tissue macrophages. This antibody reacts with neutrophils, monocytes, macrophages, and squamous mucosal epithelia and has been shown as an important marker for identifying macrophages in tissue sections.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 1 mM PBS (0.05% BSA and 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with Macrophage monoclonal antibody, clone MAC387 (Cat # MAB14434).Immunofluorescence
Flow Cytometry
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Gene Info — S100A8
Entrez GeneID
6279Protein Accession#
P05109; P06702Gene Name
S100A8
Gene Alias
60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8
Gene Description
S100 calcium binding protein A8
Omim ID
123885Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq
Other Designations
OTTHUMP00000015329|OTTHUMP00000015330|S100 calcium-binding protein A8|S100 calcium-binding protein A8 (calgranulin A)|calgranulin A|cystic fibrosis antigen
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Gene Info — S100A9
Entrez GeneID
6280Protein Accession#
P05109; P06702Gene Name
S100A9
Gene Alias
60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14
Gene Description
S100 calcium binding protein A9
Omim ID
123886Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq
Other Designations
OTTHUMP00000015331|S100 calcium-binding protein A9|S100 calcium-binding protein A9 (calgranulin B)|calgranulin B
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Interactome
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Disease
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Publication Reference
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Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody.
Flavell DJ, Jones DB, Wright DH.
The Journal of Histochemistry and Cytochemistry 1987 Nov; 35(11):217.
Application：IHC-P, IP, WB-Ce, Human, Brains, Granulocytes, Gut, Kidney, Livers, Monocytes, Lymph nodes.
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Identification of tissue histiocytes on paraffin sections by a new monoclonal antibody.
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