MVP monoclonal antibody, clone 1032
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of (A) human testicular carcinoma and (B) human breast carcinoma with MVP monoclonal antibody, clone 1032 (Cat # MAB14424).
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Specification
Product Description
Mouse monoclonal antibody raised against human MVP.
Immunogen
Proteins precipitated from human breast cancer MCF-7 cell line.
Host
Mouse
Reactivity
Human
Specificity
Recognizes a protein of 104kDa-110kDa which characterized as MVP.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of (A) human testicular carcinoma and (B) human breast carcinoma with MVP monoclonal antibody, clone 1032 (Cat # MAB14424).Immunofluorescence
Flow Cytometry
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Gene Info — MVP
Entrez GeneID
9961Protein Accession#
Q14764Gene Name
MVP
Gene Alias
LRP, VAULT1
Gene Description
major vault protein
Omim ID
605088Gene Ontology
HyperlinkGene Summary
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq
Other Designations
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Interactome
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Publication Reference
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Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell.
Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA.
The Journal of Cell Biology 1998 Jun; 141(6):1301.
Application：IP, WB-Ce, WB-Tr, Human, MCF-7 cells.
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Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia.
den Boer ML, Pieters R, Kazemier KM, Rottier MM, Zwaan CM, Kaspers GJ, Janka-Schaub G, Henze G, Creutzig U, Scheper RJ, Veerman AJ.
Blood 1998 Mar; 91(6):2092.
Application：Flow Cyt, Human, Human leukemia cells.
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Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell.
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