CEACAM1 monoclonal antibody, clone C6G9
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Specification
Product Description
Mouse monoclonal antibody raised against full length native human CEACAM1.
Immunogen
Native purified CEACAM1 from human colon adenocarcinoma cell line.
Host
Mouse
Reactivity
Human
Form
Lyophilized
Isotype
IgG1
Recommend Usage
Immunohistochemistry (0.5-2 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (1.2% sodium acetate, 2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — CEACAM1
Entrez GeneID
634Protein Accession#
P13688;P31809;P16573Gene Name
CEACAM1
Gene Alias
BGP, BGP1, BGPI
Gene Description
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Omim ID
109770Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined. [provided by RefSeq
Other Designations
CD66a antigen|antigen CD66|biliary glycoprotein adhesion molecule|carcinoembryonic antigen-related cell adhesion molecule 1
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Interactome
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Disease
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Publication Reference
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Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ.
Genomics 1988 Jul; 3(1):59.
Application:WB-Ce, Human, BT-20, LoVo cells.
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DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.
GOLD P, FREEDMAN SO.
The Journal of Experimental Medicine 1965 Mar; 121:439.
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Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains.
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