Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human rhabdomyosarcoma (A) and human testicular carcinoma (B) with PAX7 monoclonal antibody, clone PAX7/1187 (Cat # MAB14392).
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq