CDC6 monoclonal antibody, clone DCS-180
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant CDC6.
Immunogen
Recombinant protein corresponding to full length human CDC6.
Host
Mouse
Theoretical MW (kDa)
62.7
Reactivity
Human
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — CDC6
Entrez GeneID
990Gene Name
CDC6
Gene Alias
CDC18L, HsCDC18, HsCDC6
Gene Description
cell division cycle 6 homolog (S. cerevisiae)
Omim ID
602627Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq
Other Designations
CDC18 (cell division cycle 18, S.pombe, homolog)-like|CDC6 cell division cycle 6 homolog|CDC6-related protein|cell division cycle 6 protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization.
Taviaux SA, Demaille JG.
Genomics 1993 Jan; 15(1):194.
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Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively.
Sartor H, Ehlert F, Grzeschik KH, Muller R, Adolph S.
Genomics 1992 Jul; 13(3):911.
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Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization.
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