MITF monoclonal antibody, clone D5
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human MITF.
Immunogen
Recombinant protein corresponding to N-terminus of human MITF.
Host
Mouse
Theoretical MW (kDa)
52-56
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human melanoma with MITF monoclonal antibody, clone D5 (Cat # MAB14360).Immunofluorescence
Flow Cytometry
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Gene Info — MITF
Entrez GeneID
4286Protein Accession#
O75030Gene Name
MITF
Gene Alias
MI, WS2A, bHLHe32
Gene Description
microphthalmia-associated transcription factor
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000195123|OTTHUMP00000195140|homolog of mouse microphthalmia
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Interactome
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Pathway
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Disease
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Publication Reference
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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma.
Joanna Pozniak, Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Asier Antoranz, Lukas Vanwynsberghe, Ada Nowosad, Niccolò Roda, Samira Makhzami, Greet Bervoets, Lucas Ferreira Maciel, Carlos Ariel Pulido-Vicuña, Lotte Pollaris, Ruth Seurinck, Fang Zhao, Karine Flem-Karlsen, William Damsky, Limin Chen, Despoina Karagianni, Sonia Cinque, Sam Kint, Katy Vandereyken, Benjamin Rombaut, Thierry Voet, Frank Vernaillen, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Yvan Saeys, Joost van den Oor
Cell 2024 Jan; 187(1):166.
Application:IF, Human, Lymph node.
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The CD73 is induced by TGF-β1 triggered by nutrient deprivation and highly expressed in dedifferentiated human melanoma.
Caterina Giraulo, Roberta Turiello, Lavinia Orlando, Sonia Leonardelli, Jennifer Landsberg, Raffaella Belvedere, Georg Rolshoven, Christa E Müller, Michael Hölzel, Silvana Morello.
Biomedicine & Pharmacotherapy 2023 Sep; 165:115225.
Application:IF, Human, Human melanoma.
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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma.
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