INS monoclonal antibody, clone IRDN/805
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human INS.
Immunogen
Recombinant protein corresponding to full length human INS.
Host
Mouse
Theoretical MW (kDa)
6
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with INS monoclonal antibody, clone IRDN/805 (Cat # MAB14301).Immunofluorescence
Flow Cytometry
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Gene Info — INS
Entrez GeneID
3630Protein Accession#
P01308Gene Name
INS
Gene Alias
ILPR, IRDN
Gene Description
insulin
Gene Ontology
HyperlinkGene Summary
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq
Other Designations
OTTHUMP00000011161|OTTHUMP00000011162|OTTHUMP00000196038|proinsulin
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Interactome
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