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Last updated: 2017/12/10
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BIN1 monoclonal antibody, clone 99D

  • Catalog # : MAB1429
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant BIN1.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 189-398 of human BIN1.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 64.5
  • Reactivity:
  • Chicken, Human, Mouse, Pig, Rat
  • Form:
  • Lyophilized
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • Western Blot (0.25 ug/mL)
    Immunohistochemistry (Frozen sections) (0.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunocytochemistry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunocytochemistry
  • Gene Information
  • Entrez GeneID:
  • 274
  • Gene Name:
  • BIN1
  • Gene Alias:
  • AMPH2,AMPHL,DKFZp547F068,MGC10367,SH3P9
  • Gene Description:
  • bridging integrator 1
  • Gene Summary:
  • This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000162179,OTTHUMP00000162183,amphiphysin II,amphiphysin-like,box dependant MYC interacting protein 1
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