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GNRHR/LHCGR monoclonal antibody, clone GNRHR/768

  • Catalog # : MAB14276
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant human GNRHR/LHCGR.
  • Immunogen:
  • Recombinant protein corresponding to full length human GNRHR/LHCGR.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 54-60
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
    Immunofluorescence (1-2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS.
  • Storage Instruction:
  • Store at -20 to -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ovarian carcinoma with GNRHR/LHCGR monoclonal antibody, clone GNRHR/768 (Cat # MAB14276).
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 2798
  • Protein Accession#:
  • P30968;P22888
  • Gene Name:
  • GNRHR
  • Gene Alias:
  • GNRHR1,GRHR,LHRHR,LRHR
  • Gene Description:
  • gonadotropin-releasing hormone receptor
  • Gene Summary:
  • This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq
  • Other Designations:
  • gonadotropin-releasing hormone (type 1) receptor 1,leutinizing hormone releasing horomone receptor,leutinizing-releasing hormone receptor,luliberin receptor,type I GnRH receptor
  • Gene Information
  • Entrez GeneID:
  • 3973
  • Protein Accession#:
  • P30968;P22888
  • Gene Name:
  • LHCGR
  • Gene Alias:
  • FLJ41504,LCGR,LGR2,LH/CG-R,LH/CGR,LHR,LHRHR,LSH-R
  • Gene Description:
  • luteinizing hormone/choriogonadotropin receptor
  • Gene Summary:
  • This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq
  • Other Designations:
  • luteinising hormone-choriogonadotropin receptor,lutropin/choriogonadotropin receptor
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