GNRHR/LHCGR monoclonal antibody, clone GNRHR/768
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human GNRHR/LHCGR.
Immunogen
Recombinant protein corresponding to full length human GNRHR/LHCGR.
Host
Mouse
Theoretical MW (kDa)
54-60
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human ovarian carcinoma with GNRHR/LHCGR monoclonal antibody, clone GNRHR/768 (Cat # MAB14275).Immunofluorescence
Flow Cytometry
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Gene Info — GNRHR
Entrez GeneID
2798Protein Accession#
P30968;P22888Gene Name
GNRHR
Gene Alias
GNRHR1, GRHR, LHRHR, LRHR
Gene Description
gonadotropin-releasing hormone receptor
Gene Ontology
HyperlinkGene Summary
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq
Other Designations
gonadotropin-releasing hormone (type 1) receptor 1|leutinizing hormone releasing horomone receptor|leutinizing-releasing hormone receptor|luliberin receptor|type I GnRH receptor
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Gene Info — LHCGR
Entrez GeneID
3973Protein Accession#
P30968;P22888Gene Name
LHCGR
Gene Alias
FLJ41504, LCGR, LGR2, LH/CG-R, LH/CGR, LHR, LHRHR, LSH-R
Gene Description
luteinizing hormone/choriogonadotropin receptor
Gene Ontology
HyperlinkGene Summary
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq
Other Designations
luteinising hormone-choriogonadotropin receptor|lutropin/choriogonadotropin receptor
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Interactome
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Pathway
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Disease
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