ALPP monoclonal antibody, clone PL8-F6
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with ALPP monoclonal antibody, clone PL8-F6 (Cat # MAB14268).
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Specification
Product Description
Mouse monoclonal antibody raised against native human ALPP.
Immunogen
Native purified human ALPP.
Host
Mouse
Theoretical MW (kDa)
70
Reactivity
Human
Specificity
This monoclonal antibody reacts with a membrane-bound isozyme (Regan and Nagao type) of ALPP occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
Immunohistochemistry (Frozen sections) (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with ALPP monoclonal antibody, clone PL8-F6 (Cat # MAB14268).Immunohistochemistry (Frozen sections)
Immunofluorescence
Flow Cytometry
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Gene Info — ALPP
Entrez GeneID
250Protein Accession#
P05187Gene Name
ALPP
Gene Alias
ALP, FLJ61142, PALP, PLAP
Gene Description
alkaline phosphatase, placental (Regan isozyme)
Omim ID
171800Gene Ontology
HyperlinkGene Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq
Other Designations
alkaline phosphomonoesterase|glycerophosphatase|placental alkaline phosphatase
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Interactome
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Pathway
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Disease
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