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XRCC5/XRCC6 monoclonal antibody, clone KU729 (PE)

  • Catalog # : MAB14210
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native human XRCC5 and XRCC6.
  • Immunogen:
  • Nuclear extract of human HL-60 cells.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 70, 80
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes a conformational epitope of XRCC5/XRCC6 dimer, which is destroyed during Western blotting.
  • Form:
  • Liquid
  • Conjugation:
  • PE
  • Purification:
  • Protein G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (5 uL/test/million cells in 0.1 mL or 5 uL/100 uL of whole blood)
    Immunofluorescence (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% BSA, 0.05% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 2547
  • Protein Accession#:
  • P12956; P13010
  • Gene Name:
  • XRCC6
  • Gene Alias:
  • CTC75,CTCBF,G22P1,KU70,ML8,TLAA
  • Gene Description:
  • X-ray repair complementing defective repair in Chinese hamster cells 6
  • Gene Summary:
  • The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq
  • Other Designations:
  • ATP-dependent DNA helicase II, 70 kDa subunit,CTC box binding factor 75 kDa subunit,Ku autoantigen p70 subunit,Ku autoantigen, 70kDa,OTTHUMP00000028581,thyroid autoantigen 70kD (Ku antigen),thyroid autoantigen 70kDa (Ku antigen),thyroid-lupus autoantigen
  • Gene Information
  • Entrez GeneID:
  • 7520
  • Protein Accession#:
  • P12956; P13010
  • Gene Name:
  • XRCC5
  • Gene Alias:
  • FLJ39089,KARP-1,KARP1,KU80,KUB2,Ku86,NFIV
  • Gene Description:
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • Gene Summary:
  • The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
  • Other Designations:
  • ATP-dependent DNA helicase II,DNA repair protein XRCC5,Ku autoantigen, 80kDa,Ku86 autoantigen related protein 1,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD),X-ray repair, comp
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