Mouse monoclonal antibody raised against native human TNFRSF8.
Co cell line established from a patient with Hodgkin's disease of T-cell lineage.
Theoretical MW (kDa):
The epitope of this antibody is located between amino acids 112 - 412 of human TNFRSF8.
Flow Cytometry (5-10 uL/million cells in 0.1 mL) Immunofluorescence (1:50-1:100) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100) The optimal working dilution should be determined by the end user.
In tissue culture supernatant (0.05% sodium azide).
Store at 4°C.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq