Immunoprecipitation analysis of Lane 1: HeLa (after immunoprecipitation), Lane 2: HeLa (negative immunoprecipitation control), Lane 3: HeLa (no immunoprecipitation), Lane 4: BT474 and Lane 5: T47D cell lysates with TOP1 monoclonal antibody, clone 24.5 (Cat # MAB14183).
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq
DNA topoisomerase I,OTTHUMP00000031713,type I DNA topoisomerase