TNNI3 monoclonal antibody, clone TPC-110
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Specification
Product Description
Mouse monoclonal antibody raised against native human TNNI3.
Immunogen
Native purified human TNNI3.
Host
Mouse
Reactivity
Human
Specificity
Human Troponin I, amino acid sequence N24-40. Not reactive to human skeletal muscle Troponin I, human skeletal Troponin T, human cardiac Troponin T, or human Troponin C.
Form
Liquid
Purification
DEAE column chromatography
Activity
Affinity Constant: 4 x 1010 l/mol.
Isotype
IgG1
Recommend Usage
For solid phase coating (capture) or enzyme conjugation (detection).
The optimal working dilution should be determined by the end user.Storage Buffer
In 15 mM KPO4 buffer, 0.85% NaCl, pH 7.4 (0.09% sodium azide).
Storage Instruction
Store at 4°C. Do Not Freeze. Precipitation may occur upon freezing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Sandwich ELISA
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Gene Info — TNNI3
Entrez GeneID
7137Gene Name
TNNI3
Gene Alias
CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI
Gene Description
troponin I type 3 (cardiac)
Gene Ontology
HyperlinkGene Summary
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq
Other Designations
familial hypertrophic cardiomyopathy 7|troponin I, cardiac
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Interactome
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Disease
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