Western Blot analysis of Lane 1: A549, Lane 2: 293T, Lane 3: Jurkat, Lane 4: A431, Lane 5: U2OS, Lane 6: COS7 and Lane 7: 3T3 L1 cell lysates with STAT1 monoclonal antibody, clone 15H3 (Cat # MAB14168).
Immunofluorescent staining of HeLa (A), MCF-7 (B) and A2058 (C) cells (left) with STAT1 monoclonal antibody, clone 15H3 (Cat # MAB14168) (Green) compared to a negative control without primary antibody respectively (right). Blue: nuclei. Red: F-actin.
Immunoprecipitation analysis of U2OS cells with STAT1 monoclonal antibody, clone 15H3 (Cat # MAB14168). Lane 1: lysate. Lane 2: IP.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
OTTHUMP00000165047,signal transducer and activator of transcription 1,signal transducer and activator of transcription-1,transcription factor ISGF-3 components p91/p84