Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) in the cytoplasm of mouse breast (A), human lung adenocarcinoma (B) and in the nucleus and cytoplasm of human prostate (C) tissues (right) with FOXA1 monoclonal antibody, clone 3A8 (Cat # MAB14060) compared to a negative control without primary antibody respectively (left).
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq