Western blot analysis of Lane 1: HEK 293T, Lane 2: A-549, Lane 3: Jurkat, Lane 4: A-431, Lane 5: MCF-7, Lane 6: HeLa, Lane 7: U-2 OS, Lane 8: K-562, Lane 9: COS-7, Lane 10: 3T3-L1, and Lane 11: NRK cells with ACO2 monoclonal antibody, clone 7G4 (Cat # MAB13974).
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq