GP1BA monoclonal antibody, clone HIP1 (APC)
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Specification
Product Description
Mouse monoclonal antibody raised against human GP1BA.
Immunogen
Human PBMCs of a patient suffering with CLL.
Host
Mouse
Theoretical MW (kDa)
17-22
Reactivity
Human
Form
Liquid
Conjugation
APC
Purification
Protein A/G purification
Purity
>90%
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of human normal whole blood with GP1BA monoclonal antibody, clone HIP1 (APC) (Cat # MAB13912). -
Gene Info — GP1BA
Entrez GeneID
2811Protein Accession#
P07359Gene Name
GP1BA
Gene Alias
BSS, CD42B, CD42b-alpha, GP1B, MGC34595
Gene Description
glycoprotein Ib (platelet), alpha polypeptide
Gene Ontology
HyperlinkGene Summary
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq
Other Designations
platelet glycoprotein Ib alpha polypeptide|platelet membrane glycoprotein 1b-alpha subunit
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