ITGA2B monoclonal antibody, clone HIP8 (CF-Blue)
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Specification
Product Description
Mouse monoclonal antibody raised against human ITGA2B.
Immunogen
Idiopathic thrombocytopenic purpura (IPT) patient platelets.
Host
Mouse
Theoretical MW (kDa)
25
Reactivity
Human
Form
Liquid
Conjugation
CF-Blue
Purification
Protein A/G purification
Purity
>90%
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (5 uL/106 cells)
Immunohistochemistry (Frozen sections)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
Flow cytometric analysis of human normal whole blood with ITGA2B monoclonal antibody, clone HIP8 (CF-Blue) (Cat # MAB13904). -
Gene Info — ITGA2B
Entrez GeneID
3674Protein Accession#
P08514Gene Name
ITGA2B
Gene Alias
CD41, CD41B, GP2B, GPIIb, GTA, HPA3
Gene Description
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Gene Ontology
HyperlinkGene Summary
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin alpha 2b|platelet fibrinogen receptor, alpha subunit|platelet-specific antigen BAK
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