ITGA2B monoclonal antibody, clone HIP8 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against human ITGA2B.
Immunogen
Idiopathic thrombocytopenic purpura (IPT) patient platelets.
Host
Mouse
Theoretical MW (kDa)
25
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein A/G purification
Purity
>90%
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (20 uL/106 cells)
Immunohistochemistry (Frozen sections)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
Flow cytometric analysis of human normal whole blood with ITGA2B monoclonal antibody, clone HIP8 (FITC) (Cat # MAB13899). -
Gene Info — ITGA2B
Entrez GeneID
3674Protein Accession#
P08514Gene Name
ITGA2B
Gene Alias
CD41, CD41B, GP2B, GPIIb, GTA, HPA3
Gene Description
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Gene Ontology
HyperlinkGene Summary
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin alpha 2b|platelet fibrinogen receptor, alpha subunit|platelet-specific antigen BAK
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