CR1 monoclonal antibody, clone UJ11 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against human CR1.
Immunogen
Human cells of the monocyte lineage.
Host
Mouse
Theoretical MW (kDa)
280
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein A/G purification
Purity
>90%
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 uL/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).
Storage Instruction
Store in the dark at 4°C. Avoid prolonged exposure to light.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of human peripheral blood leukocytes with CR1 monoclonal antibody, clone UJ11 (FITC) (Cat # MAB13883). -
Gene Info — CR1
Entrez GeneID
1378Protein Accession#
P17927Gene Name
CR1
Gene Alias
C3BR, CD35, KN
Gene Description
complement component (3b/4b) receptor 1 (Knops blood group)
Gene Ontology
HyperlinkGene Summary
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq
Other Designations
C3-binding protein|C3b/C4b receptor|CD35 antigen|Knops blood group antigen|complement component receptor 1|complement receptor 1
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Interactome
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Disease
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