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FCGR3A monoclonal antibody, clone 3G8 (APC)

  • Catalog # : MAB13818
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against human FCGR3A.
  • Immunogen:
  • Human polymorphonuclear leukocytes.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 50-65
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Conjugation:
  • APC
  • Purification:
  • Protein A/G purification
  • Purity:
  • >90%
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (20 uL/106 cells)
    Functional Study
    Immunohistochemistry (Frozen sections)
    Immunoprecipitation
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).
  • Storage Instruction:
  • Store in the dark at 4°C. Avoid prolonged exposure to light.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Functional Study
  • Flow Cytometry
  • Flow Cytometry
  • Flow cytometric analysis of human peripheral blood lymphocytes with FCGR3A monoclonal antibody, clone 3G8 (APC) (Cat # MAB13818).
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 2214
  • Gene Name:
  • FCGR3A
  • Gene Alias:
  • CD16,CD16A,FCG3,FCGR3,FCGRIII,FCR-10,FCRIII,FCRIIIA,IGFR3
  • Gene Description:
  • Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
  • Gene Summary:
  • This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • Fc fragment of IgG, low affinity III, receptor for (CD16),Fc fragment of IgG, low affinity IIIa, receptor for (CD16),Fc gamma receptor III-A,Fc-gamma RIII-alpha,Fc-gamma RIIIa,Fc-gamma receptor III-2 (CD 16),Fc-gamma receptor IIIb (CD16),FcgammaRIIIA,OTTH
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