Western blot analysis of human Jurkat cells untreated (lane 1) or treated with pervanadate (1 mM) for 30 minutes (lane 2). The blot was probed with CBL (phospho Y700) monoclonal antibody, clone M161 (Cat # MAB1380).
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq