Western blot analysis of rabbit spleen fibroblasts serum starved for 2 hrs (lane 1) or treated with pervanadate (1 mM) for 30 minutes (lane 2). The blot was probed with GSK3B (phospho Y216) monoclonal antibody, clone M132 (Cat # MAB1373).
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene