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CR1 monoclonal antibody, clone CR1/802

  • Catalog # : MAB13261
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant human CR1.
  • Immunogen:
  • Recombinant protein corresponding to full length human CR1.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 210-220
  • Reactivity:
  • Human
  • Specificity:
  • This monoclonal antibody does not block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2.
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
    Immunofluorescence (1-2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with CR1 monoclonal antibody, clone CR1/802 (Cat # MAB13261).
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 1378
  • Gene Name:
  • CR1
  • Gene Alias:
  • C3BR,CD35,KN
  • Gene Description:
  • complement component (3b/4b) receptor 1 (Knops blood group)
  • Gene Summary:
  • This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq
  • Other Designations:
  • C3-binding protein,C3b/C4b receptor,CD35 antigen,Knops blood group antigen,complement component receptor 1,complement receptor 1
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