CDKN1B monoclonal antibody, clone KIP1/769
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon carcinoma (A), human prostate cancer (B), human cervical cancer (C) and rat colon (D) with CDKN1B monoclonal antibody, clone KIP1/769 (Cat # MAB13245).
Flow Cytometry
Flow cytometric analysis of Jurkat cells with CDKN1B monoclonal antibody, clone KIP1/769 (Cat # MAB13245). Black: Cells alone; Grey: Isotype control; Green: AF488 conjugated format of CDKN1B monoclonal antibody, clone KIP1/769.
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human CDKN1B.
Immunogen
Recombinant protein corresponding to full length human CDKN1B.
Host
Mouse
Theoretical MW (kDa)
25-26
Reactivity
Human, Rat
Specificity
This monoclonal antibody is highly specific to CDKN1B and shows no cross-reaction with other closely related mitotic inhibitors.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon carcinoma (A), human prostate cancer (B), human cervical cancer (C) and rat colon (D) with CDKN1B monoclonal antibody, clone KIP1/769 (Cat # MAB13245).Immunofluorescence
Flow Cytometry
Flow cytometric analysis of Jurkat cells with CDKN1B monoclonal antibody, clone KIP1/769 (Cat # MAB13245). Black: Cells alone; Grey: Isotype control; Green: AF488 conjugated format of CDKN1B monoclonal antibody, clone KIP1/769. -
Gene Info — CDKN1B
Entrez GeneID
1027Protein Accession#
P46527Gene Name
CDKN1B
Gene Alias
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Gene Description
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Ontology
HyperlinkGene Summary
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
Other Designations
cyclin-dependent kinase inhibitor 1B
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Interactome
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Pathway
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Disease
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