NEFH/NEFL monoclonal antibody, clone SPM145
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with NEFH/NEFL monoclonal antibody, clone SPM145 (Cat # MAB13211).
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Specification
Product Description
Mouse monoclonal antibody raised against native human NEFH/NEFL.
Immunogen
Semi-purified NEFH/NEFL from human spinal cord.
Host
Mouse
Theoretical MW (kDa)
200, 68
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with NEFH/NEFL monoclonal antibody, clone SPM145 (Cat # MAB13211).Flow Cytometry
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Gene Info — NEFH
Entrez GeneID
4744Protein Accession#
P12036;P07196Gene Name
NEFH
Gene Alias
NFH
Gene Description
neurofilament, heavy polypeptide
Gene Ontology
HyperlinkGene Summary
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq
Other Designations
neurofilament triplet H protein|neurofilament, heavy polypeptide 200kDa
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Gene Info — NEFL
Entrez GeneID
4747Protein Accession#
P12036;P07196Gene Name
NEFL
Gene Alias
CMT1F, CMT2E, FLJ53642, NF-L, NF68, NFL
Gene Description
neurofilament, light polypeptide
Gene Ontology
HyperlinkGene Summary
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq
Other Designations
light molecular weight neurofilament protein|neurofilament protein, light chain|neurofilament subunit NF-L|neurofilament triplet L protein|neurofilament, light polypeptide 68kDa|neurofilament-light
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Interactome
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Pathway
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Disease
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