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NEFH/NEFL monoclonal antibody, clone SPM145

  • Catalog # : MAB13211
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native human NEFH/NEFL.
  • Immunogen:
  • Semi-purified NEFH/NEFL from human spinal cord.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 200, 68
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with NEFH/NEFL monoclonal antibody, clone SPM145 (Cat # MAB13211).
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 4744
  • Protein Accession#:
  • P12036;P07196
  • Gene Name:
  • NEFH
  • Gene Alias:
  • NFH
  • Gene Description:
  • neurofilament, heavy polypeptide
  • Gene Summary:
  • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq
  • Other Designations:
  • neurofilament triplet H protein,neurofilament, heavy polypeptide 200kDa
  • Gene Information
  • Entrez GeneID:
  • 4747
  • Protein Accession#:
  • P12036;P07196
  • Gene Name:
  • NEFL
  • Gene Alias:
  • CMT1F,CMT2E,FLJ53642,NF-L,NF68,NFL
  • Gene Description:
  • neurofilament, light polypeptide
  • Gene Summary:
  • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq
  • Other Designations:
  • light molecular weight neurofilament protein,neurofilament protein, light chain,neurofilament subunit NF-L,neurofilament triplet L protein,neurofilament, light polypeptide 68kDa,neurofilament-light
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