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Entrez GeneID

Protein Accession#

Gene Name

KRT10

Gene Alias

CK10, K10, KPP

Gene Description

keratin 10

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq

Other Designations

cytokeratin 10

Entrez GeneID

Protein Accession#

Gene Name

KRT13

Gene Alias

CK13, K13, MGC161462, MGC3781

Gene Description

keratin 13

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described. [provided by RefSeq

Other Designations

cytokeratin 13|keratin, type I cytoskeletal 13