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HP monoclonal antibody, clone 2F4

  • Catalog # : MAB12976
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against human HP.
  • Immunogen:
  • Human plasma.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • ELISA
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50)
    Western Blot (1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In HEPES, 0.15 M NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide).
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western Blot analysis of Lane 1: HP 1-1 isolated from human plasma, Lane 2: HP 2-1 isolated from human plasma, Lane 3: HP 2-2 isolated from human plasma and Lane 4: human plasma with HP monoclonal antibody, clone 2F4 (Cat # MAB12976).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta (A) and human liver (B) with HP monoclonal antibody, clone 2F4 (Cat # MAB12976) at 1:50 dilution.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 3240
  • Gene Name:
  • HP
  • Gene Alias:
  • BP,HP2-ALPHA-2,HPA1S,MGC111141
  • Gene Description:
  • haptoglobin
  • Gene Summary:
  • This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • binding peptide,haptoglobin alpha(1S)-beta,haptoglobin alpha(2FS)-beta,haptoglobin, alpha polypeptide,haptoglobin, beta polypeptide
  • Related Disease
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